@Esben_Jensen, I used the “Normal” Mode for RS-232 on the LS-7601, which specifies Bitrate 9600, 8 bits, Parity Even, and 1 Stop Bit, and each command ending with hex character 13 (H0D). Here are some screenshots of my setup, although Master Mode on Communicator settings may work better for you.
Since you are using the HMS-EN2SE-R these settings may not apply to you, most especially Fieldbus Type.
Communicator settings, again Master Mode may work better here for you; I have only tried generic data mode.
Here are the RS-232 settings, make sure these match the LS-7601
And here are some examples of commands being sent to the LS-7601. These and others are all in chapter 8 of the manual for the LS-7601.
Hopefully these help, let me know if you have any other questions.